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Freeze Thaw or Cyclic Temperature stress tests are designed on the knowledge of the product so as to mimic likely storage conditions. The period of cycle is mostly considered 24 hours since the diurnal rhythm on earth is 24 hours.

Additionally, the distribution environment can vary greatly, especially when a drug product is shipped between various climatic zones. Seasonal changes, mode of transportation, and the number of drop-off points are also variables that should be considered within the pharmaceutical supply chain. Drug products requiring controlled-temperature storage conditions must be distributed in a manner that ensures that the product quality will not be adversely affected. With the exception of short transit times within the same climatic zone, it is virtually impossible to validate a shipping method against all environmental conditions.

Therefore, distribution stability studies are designed to generate additional data to complement preformulation development and routine (ICH) Q1A(R2).

NEWTRONIC Freeze Thaw Chambers control a broad temperature range of -20 °C to 50 °C thereby offering the flexibility to simulate a broad range of conditions. The min temperature, max temperature & cyclic time are all user-settlable thereby allowing the user to program a specific profile for their studies. Automatic cycling between the setpoints enables rapid simulation of conditions & the need to replicate freezing and thawing during product testing.

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  • High-speed data transfer
  • Significantly faster than serial(RS-485) communication
  • Global standard for communication protocol
  • No need for a separate PC interface
  • Data Operations from any PC over the LAN


  • Complete Operations driven through PLC
  • No Data Loss: Data Storage of upto 1000 readings on the PLC itself
  • At an interval of 30 mins, data upto 20 days is stored on the PLC itself
  • Facility to send emails directly from the PLC


  • All operations through a single 4" Color touch screen display
  • PLC IP Address setting
  • Component Working Hours
  • Standby system change over
  • Password protection for set values and calibration mode


  • When an alarm is triggered, an e-mail is sent to the registered PC or mobile address
  • *connection to a mail server is required to use e-mail alert.

Complete Range of Alarms

  • Temperature & Humidity Deviations
  • Door Opening
  • Component Failure
  • Mains Failure


  • Mobile Alert system
  • Time of Alarm transmission
  • Name of Equipment
  • Transmitted Message (Equipment Name, Alarm time, Type of Alarm & Limits)


  • Temperature Overshoot/Undershoot
  • Delay Timer to safeguard the Compressor
  • MCB to cut-off over-current supply
  • Standby Controlling Sensor upon failure of Primary
  • Emergency Bell switch inside the Chamber


  • 21 CFR Part 11 Ready
  • Single software suitable for upto 20 equipments
  • Automatic daily data back-up
  • Alarm logs. Alarm acknowledgement with e-signatures
  • Audit trails
  • MKT Calculations
  • Graphical viewing & data trending
  • Data export in pdf format


  • IQ, OQ, PQ
  • Calibration certificates
  • Operations & maintanance manuals
  • GA & Electrical drawings
  • Material test certificates
  • Training to end-users
Temperature Range -20°C to 50°C
Double walled with 80mm PUF insulated modular panels with easy on-site assembly System is made up of split type condenser unit in well-ventilated area to avoid throw of hot air in the room
SS 304 Interior & Exterior either SS 304 or Powder Coated G.I. Stand by humidity system
Stainless Steel Trays Complete Operations driven through PLC with data logging capacity of upto 1000 readings & email facility
Observation window - 300 x 300 mm High speed Ethernet based communication
Illuminated working area All operations through a single 4" Color Touch Screen
U-shaped SS tubular heaters High-quality German Make temperature humidity sensor with 4-20mA output
Flooring of Linoleum carpet Safety devices: Low & High temperature cut-off settable thermostats & high humidity cut-off device
Forced air circulation for uniform temperature Audio/Visual alarms for deviations
Non Condensing steam injection type humidity system with standby heater & auto switch overs Complete with IQ, OQ, PQ & Operations & Maintenance Manual
CFC free cooling system consisting of hermetically sealed compressor coupled with evaporation coil & condenser

Power supply: 230/415 volts 50 Hz main supply. Also available with 60 Hz Cycle.
ICDAS - a Single software installation for all Newtronic make equipment's Door Access system
Remote alarm system suitable for 4 nos. Newtronic make equipments Mobile Alert system
Model Capacity Internal Size External Size Trays Qty. Tray size Approx. Weight (Kg) Approx. Weight (Kg)
CuFt. Liter (H*W*D )mm (H*W*D) mm (W*D)mm Eqip. Ship.
NLFT7MI 7 200 510 x 560 x 700 1500 x 720 x 880 2 540 x 605 175 250
NLFT11MI 11 300 910 x 560 x 590 1955 x 720 x 770 3 540 x 495 225 300
NLFT14MI 14 400 910 x 560 x 785 1955 x 720 x 965 3 540 x 690 275 350
NLFT25MI 25 700 1200 x 800 x 730 2120 x 960 x 960 4 780 x 635 300 375
NLFT34MI 34 1050 1200 x 1200 x 730 2110 x 1360 x 960 8 510 x 635 325 425
NLFT54MI 54 1500 1200 x 1500 x 830 2110 x 1660 x 1060 8 660 x 735 350 450

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